4-Demethyl simmondsin from Simmondsia chinensis

نویسندگان

  • M. Van Boven
  • M. Cokelaere
  • E. Decuypere
چکیده

Jojoba seed meal (Simmondsia chinensis) contains approximately 15% glucosides identified as simmondsin, 5-demethyl simmondsin, didemethyl simmondsin, along with simmondsin 2%-ferulate, 4-demethyl simmondsin 2%-ferulate, and 5-demethyl simmondsin ferulate. The new simmondsin derivative was isolated from jojoba meal by a combination of column chromatography and preparative HPLC and identified by 2D-NMR and L-SIMS as 2-(cyanomethylene)-3,4-dihydroxy-5-methoxycyclohexyl b-D-glucoside or 4-demethyl simmmondsin. © 2000 Elsevier Science B.V. All rights reserved.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pii: S0926-6690(00)00074-1

Simmondsin and its analogues, demethyl-, didemethylsimmondsins (DMS/DDMS) and the 2%and 3%-simmondsin ferulates are components isolable from jojoba (Simmondsia chinensis) seed meal. While the parent compound, simmondsin, is reported to exhibit anorexic properties, its demethylated analogues not only lack this behavior, they also have no identifiable market value. To create optimum utilization o...

متن کامل

Interlaboratory comparison of simmondsin analysis

Eleven samples containing various amounts of simmondsin (S), simmondsin ferulate (SF), demethyl simmondsins (DMS) and didemethyl simmondsins (DDMS) were analyzed by five different laboratories. The samples were made from chromatographically pure simmondsin, animal feed formulations containing jojoba meal, defatted jojoba meal, water extracts of jojoba meal and combinations of these ingredients....

متن کامل

The detrimental effect of simmondsin on food intake and body weight of rats

Background: Simmondsin is a cyanomethylene glycoside, derived from the desert shrub, Simmondsia chinensis. Simmondsin has been reported to produce weight loss and to decrease food intake, an effect that can be blocked by treatment with an inhibitor of cholecystokinin. Study design: Six experiments were conducted on male Sprague–Dawley rats. Results: In two acute experiments where simmondsin was...

متن کامل

Feruloyl esterase hydrolysis and recovery of ferulic acid from jojoba meal

There is growing interest in recovering ferulic acid from plant sources for use as feedstock for several high-value applications. Jojoba meal was examined as a potential source of ferulic acid. The feruloyl esterase domain of the Clostridium thermocellum cellulosomal xylanase was employed to hydrolyze ferulic acid from defatted jojoba meal. Esterase treatment produced 6.7 g of ferulic acid/kg o...

متن کامل

Beneficial Effect of Jojoba Seed Extracts on Hyperglycemia-Induced Oxidative Stress in RINm5f Beta Cells

Hyperglycemia occurs during diabetes and insulin resistance. It causes oxidative stress by increasing reactive oxygen species (ROS) levels, leading to cellular damage. Polyphenols play a central role in defense against oxidative stress. In our study, we investigated the antioxidant properties of simmondsin, a pure molecule present in jojoba seeds, and of the aqueous extract of jojoba seeds on f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2000